Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0000010
PubChem CID
Molecular Formula
C21H21N7O3S
Molecular Weight
451.143 g/mol
Synonyms/Alias
SMR000253856|MLS000336302|MLS003913113|CHEMBL1441121|HMS2530N18|AKOS033738324|AB00549089-06|Z20241960
InChI Key
PUYQLOANGFEUEN-UHFFFAOYSA-N
InChI
InChI=1S/C21H21N7O3S/c1-2-26(16(29)13-32-21-25-24-15-10-6-7-11-27(15)21)17-18(22)28(20(31)23-19(17)3...
IUPAC Name
N-(6-amino-1-benzyl-2,4-dioxopyrimidin-5-yl)-N-ethyl-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)acetamide
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

53 56 0 0 0 0 0 0 0 0999 V2000
-0.5904 3.3083 2.7569 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.2560 1.9390 2.1729 C 0 0 0 0 0 0 0 0 0 0 0 0
0.2201 2...

Experimental Data

Activity Data

Target Ion Channel
Voltage-gated inwardly rectifying potassium channel KCNH2
Uniprot Accession Number
Function
Inhibitor
Species
Homo sapiens (Human)
IC50
N/A (Not available)
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
14.59620% inhibition at 1uM

Experimental Conditions

pH
pH 7.4
Holding Potential
−70 mV mV
Temperature
Room Temperature
Test Method
Patch-clamping
Test Species
Chinese hamster ovary (CHO) cells

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
32
Rotatable Bonds
7
logP
2
Complexity
771
TPSA (Ų)
151
H-Bond Donors
2
H-Bond Acceptors
7
Ring Count
4
New Search